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Original Article
Predictive factors for severe infection among febrile infants younger than three months of age
Eun Young Cho, Hwa Song, Ae Suk Kim, Sun Ju Lee, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Kwan Lee, Byoung Chan Park
Clin Exp Pediatr. 2009;52(8):898-903.   Published online August 15, 2009

Purpose:This study investigated the predictive factors for identifying infection-prone febrile infants younger than three months. Methods:We conducted a retrospective study of 167 infants younger than three months with an axillary temperature >38℃ who were hospitalized between 2006 and 2008. If they met any of the following criteria, positive blood culture, CSF WBC ≥ 11/mm3 or positive CSF culture, urinalysis WBC ≥6/HPF and positive...
Medical Lecture Course
CpG DNA for Treatment of Allergic Diseases
Sung Min Choi
Clin Exp Pediatr. 2005;48(3):251-259.   Published online March 15, 2005
Atopy is a highly prevalent and serious health problem. The prevalence and severity of asthma and allergic diseases have increased over recent decades, particularly in industrialized nations. Early life infections may protect against the development of atopy and allergic diseases like asthma. The inverse relationship between the incidence of atopy and childhood infections has led to the 'hygiene hypothesis', which...
Case Report
A Case of Hereditary C7 Deficiency Associated with Meningococcal Meningitis
Hyun Woo We, Won Duck Kim, Sun Ju Lee, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Gyoung Yim Ha
Clin Exp Pediatr. 2004;47(7):799-802.   Published online July 15, 2004
The complement system is composed of more than 25 different proteins and is usually divided into classical and alternative pathways. Complement component 7(C7) is one of the five terminal complement proteins that, upon activation of either the classical or the alternative pathway, interacts sequentially to form a large protein-protein complex, called membrane attack complex(MAC). Assembly of the MAC on target...
Original Article
Clinical and Virologic Study of Aseptic Meningitis
Hyun Ji Kim, Hae Kwan Cheong, Cheoll Jung, Kyu Man Lee, Young Mee Jee, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2004;47(4):392-398.   Published online April 15, 2004
Purpose : The cause of aseptic meningitis remains mostly unknown because viral culture and identification is difficult. Thus, we report a study on 123 children with aseptic meningitis in Gyeongju in 2002 to identify the causing virus and the relationship with the clinical manifestation. Methods : We prospectively investigated the patients, admitted to Dongguk University Hospital, into two groups between April...
Case Report
A Case of Klippel-Trenaunay Syndrome Combinded with Sturge-Weber Syndrome
Mi Young Kim, So Young Lee, Na Yeon Kim, Sun Ju Lee, Won Duck Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2003;46(9):909-912.   Published online September 15, 2003
Klippel-Trenaunay syndrome is a rare mesodermal phakomatosis characterized by cutaneous haemangiomata(usually unilateral and involving an extremity), venous varicosities and osseous and soft tissue hypertrophy, of the affected limb. Sturge-Weber syndrome, also a mesodermal pharkomatosis, is characterized by a port-wine nevus, which is present from birth and covers the face and cranium in the territory of the first division of the...
A Case of Partial Inverted Duplication of Chromosome 7q
Hyun Ji Kim, So Young Lee, Mi Young Kim, Chung Sun Baek, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2003;46(5):510-513.   Published online May 15, 2003
Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long...
Original Article
The Difference between Clinical Manifestations and Feeding or Delivery Methods in Healthy Full-term Neonates and Those with Nosocomial Rotaviral Infection
So Young Lee, Hyun Ji Kim, Mi Young Kim, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2003;46(5):454-458.   Published online May 15, 2003
Purpose : Rotavirus is the main cause of infantile diarrheal disease worldwide. The purpose of this study is to assess the difference between clinical manifestations and feeding or delivery methods in healthy full-term neonates and those with nosocomially-acquired rotaviral infection. Methods : The study was conducted on 348 babies who were delivered in Dongguk University Kyongju Hospital from Jan 1...
Case Report
A Case of Aseptic Meningitis Following Administration of Intravenous Immunoglobulin in A Patient with Idiopathic Thrombocytopenic Purpura
Su Jin Kim, Ji Eun Kim, Hei Won Hwang, Ji Sun Mok, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
Clin Exp Pediatr. 2001;44(7):823-826.   Published online July 15, 2001
Intravenous immunoglobulin(IVIG) has been widely used to treat idiopathic thrombocytopenic purpura in childhood. Aseptic meningitis has been reported as a rare complication of IVIG therapy. This report is on an 11 year-old boy with ITP who suffered from aseptic meningitis following the administration of IVIG. He was given 1 g/kg of IVIG for 2 days, and on the fourth day...
Two Cases of Leigh Disease in Siblings
Su Jin Kim, Ji Eun Kim, Hei Won Hwang, Ji Sun Mok, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
Clin Exp Pediatr. 2001;44(6):718-722.   Published online June 15, 2001
Leigh disease is a familial and degenerative disorder characterized by focal, bilateral, and usually symmetric lesions of the both gray and white matter in the brain and the spinal cord. The clinical course is variable, but in most cases, the prognosis is poor with subacute progression leading to death within months or years of life. The pathogenesis was known as...
Original Article
A Clinical Study of Intravenous Gamma Globulin Re-treatment in Kawasaki Disease
Na Yeon Kim, Chun Hyuk Chang, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
Clin Exp Pediatr. 2000;43(2):223-228.   Published online February 15, 2000
Purpose : Intravenous gamma globulin(IVGG) treatment has reduced symptoms and complications in Kawasaki disease(KD). However, fever persisted in 20-30% of the patients, and there are no reliable data on the indication and dosage of IVGG re-treatment. Therefore, we tried to reveal the effectiveness of IVGG re-treatment and to find risk factors in predicting the re-treatment. Methods : Among 57 patients with...
Case Report
A Case of Ectopic CD7(+) Congenital Monocytic Leukemia
Na Yeon Kim, Dong Seok Lee, Jin Hwa Jeong, Sung Min Cho, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Kyung Im Ha
Clin Exp Pediatr. 1999;42(7):1003-1007.   Published online July 15, 1999
Congenital acute leukemia is a rare disorder with approximately 200 cases reported. It is defined as a childhood leukemia occurring at birth or before 1 month of age at a rate of 1%. Acute leukemias are generally classified according to morphology, cytochemistry and cell surface marker expression. Most leukemias conform to an ordered lineage-specific pattern of gene expression, but a...
A Case of Nonsyndromic Paucity of Interlobular Bile Ducts in Down Syndrome
Chun Hyuk Chang, Jun Ho Kim, Sun Ju Le, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Tae Jung Jang
Clin Exp Pediatr. 1999;42(6):858-862.   Published online June 15, 1999
The nonsyndromic paucity of interlobular bile ducts, which belongs to intrahepatic biliary atresia, is characterized by conjugated hyperbilirubinemia, suggesting cholestasis in newborn infants it has little relationship with extrahepatic congenital abnormalities. Pathologic findings through percutaneous liver biopsy show portal changes(duct paucity and fibrosis) and lobular changes(cholestasis, giant cell transformation, extramedullary hematopoiesis and perisinusoidal fibrosis). The overall incidence of intrahepatic biliary...
Original Article
Study of Nosocomial Infection of Rotavirus in Preterm and Full-term Neonates
Kwang Ok Chung, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Sun Hee Yu
Clin Exp Pediatr. 1999;42(3):332-338.   Published online March 15, 1999
Purpose : The present study was designed to investigate rotavirus infection by comparing clinical characteristics of the nosocomial infection of rotavirus between preterm and full-term neonates. Methods : The subjects were admitted from May to December, 1996. In 71 preterms, 44 were Rotazyme positive, 27 were negative, and in 321 full-terms, 64 were Rotazyme positive, 257 were negative. We studied the...
Case Report
A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly
Kwang Ok Chung, Na Yeon Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(6):845-849.   Published online June 15, 1998
Neonatal hyperthyroidism is a very rare disorder occurring typically in the offspring of patients with Graves' disease or chronic thyroiditis. It is caused by the transplacental passage of thyroid stimulating antibodies(TSAb) from the mother to the fetus. There has been few reports of neonatal hyperthyroidism associated with congenital anomalies. We experienced a case of neonatal hyperthyroidism with unilateral microtia and agenesis of external auditory canal...
Original Article
Retrospective 3-year Clinical Study of Enterobacter Bacteremia in Neonatal Intensive Care Unit
Kwang Ok Chung, Chun Hyuk Chang, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(4):466-471.   Published online April 15, 1998
Purpose : Enterobacter is one of the important organisms in neonatal intensive care unit. We reviewed the clinical characteristics, underlying diseases, invasive procedures during admission, mortality and antibiotic sensitivity of Enterobacter infection in NICU. Methods : We retrospectively reviewed 21 neonatal patients whose blood cultures yielded Enterobacter between June 1994 and June 1997 at Dongguk University Hospital. Results : Blood cultures were positive in 62...
Case Report
A Case of Lacquer-Thinner Intoxication
Young Soo Baik, Hee Sin Ko, Kyung Bae Kwon, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Jeong Ok Choi, Hyun Jong Sin
Clin Exp Pediatr. 1995;38(5):713-718.   Published online May 15, 1995
We experienced a case of Lacquer-Thinner intoxication in a 14 month old male infant who s uffered from aspiration pneumonia, gastrointestinal bleeding, acute hepatitis, acute renal failure, respiratory failure, disseminated intravascular coagulopathy, and focal myoclonic seizure. Lacquer-Thinner is composed of toluene, xylene, methyl ethyl ketone, n-butyl alcohol, ethylene glycol monoethyl ether, and isophorone. The main components are toluene and xylene. Th...
Original Article
Percutaneous transluminal balloon valvuloplasty for congenital pulmonary valvular stenosis.
Sung Min Choi, Sang Bum Lee, Doo Hong Ahn, Yong Joo Kim
Clin Exp Pediatr. 1991;34(3):311-316.   Published online March 31, 1991
Congenital pulmonary valvular stenosis was relieved by percutaneous balloon valvuloplasty during cardiac catheterization on 8 children aged 14 months to 8 years. Before dilatation, the transpulmonary systolic pressure gradients ranged from 33 mmHg to 79 mmHg (Mean:52.00 ± 18.16 mmHg). There were significant reduction in the transpulmonic systolic pressure gradients immediate after balloon dilatation (Mean:17.38±11.16mmHg). In follow up 4 patients, this decreased pressure gradients have...
Assessment of Cardiac Output by Doppler Ultrasound Technique Alone.
Young Ho Ahn, Sung Min Choi, Nam Geun Heo, Sang Bum Lee
Clin Exp Pediatr. 1990;33(8):1074-1080.   Published online August 31, 1990
The normal range of ascending aortic blood velocity was determined in 23 healthy children including 8 newborn infants and compared with 12 anemic children, using a pulsed Doppler ultrasound technique from suprasternal long axis view. Integration of the area under the velocity-time curve for each heart beat gave stroke distance, which, when multiplied by heart rate, gave minute distance. Stroke distance and minute distance are...
The Effect of Low-Dosage Alpha-Interferon Therapy in Children with Chronic Active Hepatitis B.
Hee Kyung Kim, Sung Min Choi, Cheol Woo Ko, Kun Soo Lee, Ja Hoon Koo, Doo Hong Ahn
Clin Exp Pediatr. 1990;33(7):915-922.   Published online July 31, 1990
A clinical trial was conducted to determine the effect of low-dosage recombinant a-interferon therapy in children with HBs Ag and HBe Ag positive chronic active hepatitis. Studied patients consist of 7 biopsy-proven children (aged 6.5-11.5 yr). After 16 weeks of therapy, following results were obtained. Out of 7 HBe Ag positive cases, 5 cases (71.4%) were converted to HBe Ag negative state. One of two...
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